By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure known as affinity maturation. a bunch produces antibodies with successively higher affinities with repeated publicity to an analogous antigen, that's the primary in which such a lot vaccines work.
Affinity maturation depends on hypermutation, an iterative technique of mutation at antibody-encoding genes, by way of optimistic choice of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is admittedly required for hypermutation. This used to be in 2002 via proof that reduction without delay edits the DNA that encodes an antibody in an activated B telephone. a lot has when you consider that been learnt in regards to the biochemistry and law of relief, however the mechanism wherein it truly is recruited particularly to antibody-encoding genes continues to be enigmatic. realizing this recruitment is clinically major simply because off-target reduction job at oncogenes may end up in chromosomal translocations and tumorigenesis.
This booklet summarizes the examine on reduction within the context of its important position within the affinity maturation of B cells.
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Extra info for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin